Speaker: Dr. Teresa Lee, University of Massachusetts Lowell
Title: “Transgenerational longevity requires DAF-12 germline-to-soma signaling in C. elegans”
Abstract: Generational studies suggest that the experiences of ancestors can affect the health of their descendants, in part by altering how genomes are packaged as chromatin. We have developed a novel C. elegans model for transgenerational epigenetic inheritance to examine how heritable chromatin landscapes affect gene regulation and complex traits like lifespan. To examine the mechanism of transgenerational lifespan extension, we test the involvement of DAF-12, a nuclear hormone receptor required for germline-to-somatic signaling. Taken together, these findings highlight the complex relationship between chromatin state and germline-to-soma signaling during important life history decisions.

The Molecular Biosciences Interest Group (MBIG) seminar series highlights work done on a broad range of science such as neurodevelopment, gene regulation, and cancer by scientists using biological approaches that utilize biochemistry, molecular and cell biology, and genetics.  Guest speakers come from local, regional, and national universities to share their research work. The MBIG seminar will take place in-person on Fridays from 12:20 – 1:45 pm in the Clendenin Building, room CL 2010. All faculty, staff, students, and alumni are invited to attend.