BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
X-WR-CALNAME:MS in Chemical Sciences Thesis Defense
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20261016T030638Z
UID:tag:localist.com\,2008:EventInstance_49391045882677
DTSTART:20250416T173000Z
DTEND:20250416T183000Z
DESCRIPTION:Speaker: Md Taimuzzaman Sharif\, MSCB student\nTitle: Developme
 nt of Cyclic and Bicyclic Peptides Against the Main Protease (Mpro) of SAR
 S-CoV-2\nAbstract: Severe Acute Respiratory Syndrome (SARS-CoV-2) virus an
 d its variants are responsible for Coronavirus disease 2019 (COVID-19) wit
 h more than seven million deaths since 2019. Main protease (Mpro) is one o
 f the vital enzymes for the replication of SARS-CoV-2 and ultimate target 
 for developing drugs. The inhibition of this viral enzyme effectively inte
 rrupts the formation of functional viral proteins required for the viral g
 rowth. Several small-molecule drugs are available against COVID-19. Howeve
 r\, they often demonstrate lower target specificity\, higher adverse effec
 ts and lead to resistance on prolong use. Peptide therapeutics\, in contra
 st\, are highly target specific and thus induce less toxic effect. However
 \, they have some limitations such as flexible secondary structure\, prote
 olytic instability\, poor cell permeability and shorter half-life. Cycliza
 tion can reduce proteolytic instability\, increase cell permeability and b
 ioavailability. Previous studies from our group demonstrated that Temporin
  L like peptide (TLP) could effectively inhibit the main protease\, howeve
 r\, this peptide showed a short half-life. In this study\, four cyclic and
  four bicyclic peptides have been synthesized from three linear TLP analog
 ues using hydrophobic linkers such as Hexafluorobenzene (C6F6)\, α\, α
 ’-Dibromo-P-Xylene and α\, α’-Dichloro-P-Xylene. Moreover\, bicyclic
  peptides have been synthesized using another two hydrophobic scaffolds su
 ch as 1\,3\,5-triacryloylhexahydro-1\,3\,5-triazinane (TATA) and 1\,3\,5-t
 ris(bromomethyl)benzene (1\,3\,5-TBMB). All peptides have been characteriz
 ed by mass spectrometry. Fluorescence resonance energy transfer (FRET) and
  selected ion monitoring (SIM) based LC-MS assays have been used to invest
 igate the in-vitro inhibition efficiency of these analogues. Bicyclic pept
 ides showed strong inhibition efficiency compared to their linear counterp
 arts. Future studies will be directed to investigate gastric\, intestinal\
 , serum stability and cell viability of the best analogue.
GEO:34.035952;-84.583586
LOCATION:Clendenin Building\, CL 1009
SUMMARY:MS in Chemical Sciences Thesis Defense
URL;VALUE=URI:https://calendar.kennesaw.edu/event/mscb-thesis-defense-04162
 5
CATEGORIES:Lectures & Guest Speakers
END:VEVENT
END:VCALENDAR